Yup, it does help!

After running the app on a 2012 McBook Pro, the unit does appear to operate with less latency after cleaning orphaned system and cache files along with logs.
Additionally, my work requires that a recognized antivirus be installed; I’ve replaced Kaspersky with Bitdefender and the profomance of this OS X El Capitan laptop has improved significantly.

G-Nav about Tweak and Tuneup, v1.6.0