Performance improvement

My MBP has been getting slower by the hour. this is my 3rd disc cleaner. It “appears” to be doing what it says but so do the others (Disc Dr and Space Gremlin). I have yet to notice any performance improvement. Still staring at they G%&#mn pinwheel (or beachball?) and its still driving me nuts. Is there something that the system cleaner should be targeting? Feedback please!

garx02 about Tweak and Tuneup